STAT6

signal transducer and activator of transcription 6

Ensembl:
ENSG00000166888
UniProt:
P42226
OMIM:
601512
Synonyms:
D12S1644, IL-4-STAT

Cilia effects upon perturbation of STAT6

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance

Subcellular localization

cilia, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • T cell biology
  • Transcription regulation

Function

The PC1 tail interacts with the transcription factor STAT6 and the coactivator P100, and it stimulates STAT6-dependent gene expression(16399078).