STK11

Cilia effects upon perturbation of STK11

Cilia number / % ciliated:

Decreased cilia number

Ciliogenesis screen results (5 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=5, lfc=2.57) PMID:30270045

Subcellular localization

cilia, cytosol, nucleus

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• Metabolism
• T cell biology
• Neurogenesis & migration
• Signaling (Hedgehog, GPCRs, ion channels)
• Transcription regulation

Function

Downregulated in diseases associated with ciliopathies, including BBS, PKD and PHP. Regulates multiciliogenesis and differenciation of ciliated cells by phosphorylating MARK3 which supresses ERK1/2 (31636950). Required for CCL2 regulation within cilia, via interactions with NPHP1, ANKS3 and NEK7 (29925518). Bending of cilium activates Lkb1 pathway, which inhibits mTORC1 activity and regulation cell size (20972424). Duct-specific deletion causes duct dilations and shorter cilia with swollen tips, indicative of perturbed intraciliary transport (28159992).