STK33

serine/threonine kinase 33

Ensembl:: ENSG00000130413
UniProt:: Q9BYT3
OMIM:: 607670

Cilia effects upon perturbation of STK33

Ciliogenesis screen results (2 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: increased fasting circulating glucose level, thrombocytopenia
Mouse ciliopathy phenotype:: male infertility

Subcellular localization

flagella

Functional category

Reproduction & sperm

Function

Stk33 is essential for spermiogenesis and male fertility, and Stk33 influences manchette function and sperm tail formation(29155043).

Model organism evidence

Mus musculus (1 reference)

STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate Sperm Flagella Assembly in Spermiogenesis.

PMIDs: 37146716

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