STK36

Cilia effects upon perturbation of STK36

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

Shorter cilia

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.37) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

abnormal sinus arrhythmia, increased urine microalbumin level

Ciliopathy associations

• Primary Ciliary Dyskinesia

References: PMID:28543983, PMID:19305393

Subcellular localization

cilia, nucleus

References: PMID:41410385, PMID:19305393, PMID:23907739, PMID:28543983, PMID:21746835

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• Signaling (Hedgehog, GPCRs, ion channels)
• Transcription regulation

Function

Also knwown as FU. Participates in Hh signaling, 9+2 cilia biogenesis and function, as well as assembly or maintenance of the central pair apparatus. Interacts with Kif27 (19305393), Spag16 and Pcdp1 (23907739). Required for cilia orientation and the integrity of the whole radial spokes head. Essential for recruiting radial spokes head proteins to the axoneme. Mutations are associated with a novel PCD variant (28543983). Stk36 null show craniofacial abnormalities and defects in organs where hedgehog signaling is required (21746835).