STK38L

serine/threonine kinase 38 like [Source:HGNC Symbol,Acc:HGNC:17848]; serine/threonine kinase 38 like

Ensembl:
ENSG00000211455
UniProt:
Q9Y2H1
OMIM:
615836
Synonyms:
KIAA0965, NDR2

Cilia effects upon perturbation of STK38L

Cilia number / % ciliated:
Decreased cilia number

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.92) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

  • Leber Congenital Amaurosis
  • Retinal Dystrophy/Degeneration

Subcellular localization

basal body, centrosome, cilia, cytosol, peroxisome

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Ciliary membrane; Small GTPases; Metabolism; Trafficking (BBSome, small GTPases, vesicular transport, ATPases); Ciliary assembly/disassembly

Function

Phosphorylates Rabin8 which is crucial role in ciliogenesis. Regulates the process of vesicular trafficking and tethering to the pericentrosome, promoting local activation of Rab8 and ciliary membrane formation. Defects in NDR2-mediated Rabin8 phosphorylation impair preciliary membrane assembly and ciliogenesis, leading to accumulation of Rabin8-/Rab11-containing vesicles at the pericentrosome. Knockdown in RPE1 cells suporesses ciliogenesis (23435566, 28122914). Mutated in canine early reti l degeneration, suggesting a role in photoreceptor cell function (20887780).; A serine/threonine kinase (NDR2) crucial for early ciliogenesis. Promotes cilia formation by phosphorylating Rab-binding protein Rabin8, thereby activating the small GTPase Rab8 at the centrosome(28122914).

Model organism evidence

Xenopus (1 reference)

Rabin8 (also known as RAB3IP), an effector of Rab11 proteins and a nucleotide exchange factor (GEF) for Rab8 proteins, is phosphorylated at S272 by NDR2 kinase (also known as STK38L), the canine early retinal degeneration (erd) gene product linked to the human ciliopathy Leber congenital amauros

PMIDs: 39774853