STK38L

Cilia effects upon perturbation of STK38L

Cilia number / % ciliated:

Decreased cilia number

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.92) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

• Leber Congenital Amaurosis
• Retinal Dystrophy/Degeneration

References: PMID:20887780, PMID:39774853

Subcellular localization

basal body, centrosome, cilia, cytosol, peroxisome

References: PMID:23435566, PMID:28122914

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
• Actin & cytoskeleton regulation
• Signaling (Hedgehog, GPCRs, ion channels)
• Ciliary membrane; Small GTPases; Metabolism; Trafficking (BBSome, small GTPases, vesicular transport, ATPases); Ciliary assembly/disassembly

Function

Phosphorylates Rabin8 which is crucial role in ciliogenesis. Regulates the process of vesicular trafficking and tethering to the pericentrosome, promoting local activation of Rab8 and ciliary membrane formation. Defects in NDR2-mediated Rabin8 phosphorylation impair preciliary membrane assembly and ciliogenesis, leading to accumulation of Rabin8-/Rab11-containing vesicles at the pericentrosome. Knockdown in RPE1 cells suporesses ciliogenesis (23435566, 28122914). Mutated in canine early retinal degeneration, suggesting a role in photoreceptor cell function (20887780).; A serine/threonine kinase (NDR2) crucial for early ciliogenesis. Promotes cilia formation by phosphorylating Rab-binding protein Rabin8, thereby activating the small GTPase Rab8 at the centrosome(28122914).