STOM

stomatin

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000148175
UniProt:: P27105
OMIM:: 133090
Synonyms:: BND7, EPB7, EPB72

Ciliogenesis screen results (5 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Failler/Valderrama et al. 2021 (siRNA) [siRNA]: Negative Regulator (Ciliogenesis Candidate) PMID:33206585

Subcellular localization

cilia, endosome, mitochondria

References: PMID:35794236

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Viral interactions
Signaling (Hedgehog, GPCRs, ion channels)

Function

STOM mainly localizes in the knob/ciliary region of the OSNs while in the cell body it is detected in puncta. STOM and STOML3 share a similar expression pattern and STOML3 is necessary for STOM to properly localize to OSN cilia(35794236).

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