STOM

stomatin

Ensembl:
ENSG00000148175
UniProt:
P27105
OMIM:
133090
Synonyms:
BND7, EPB7, EPB72

Cilia effects upon perturbation of STOM

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Failler/Valderrama et al. 2021 (siRNA) [siRNA]: Negative Regulator (Ciliogenesis Candidate) PMID:33206585

Subcellular localization

cilia, endosome, mitochondria

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

STOM mainly localizes in the knob/ciliary region of the OSNs while in the cell body it is detected in puncta. STOM and STOML3 share a similar expression pattern and STOML3 is necessary for STOM to properly localize to OSN cilia(35794236).

Model organism evidence

C. elegans (1 reference)

The presence of stomatin-IR paralleled the stages of ciliogenesis in airway development, and its appearance preceded the elongation of the axoneme and the cilial outgrowth.

PMIDs: 12759749