STOML3

stomatin like 3

Ensembl:
ENSG00000133115
UniProt:
Q8TAV4
OMIM:
608327
Synonyms:
EPB7.2L, SRO

Cilia effects upon perturbation of STOML3

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.06) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Localizes to Basal Body, mechanosensing channel. BBS4 snd BBS8 knock-out impede its function. (17959775, 21646512). Localised to olfactory cilia of mature olfactory sensory neurons. Involved in olfactory sig ling (12122055).

Model organism evidence

C. elegans (1 reference)

Our findings suggest a hitherto unrecognized, but essential, role for mammalian basal body proteins in the acquisition of mechano- and thermosensory stimuli and highlight potentially clinical features of ciliopathies in humans.

PMIDs: 17959775