STOML3

stomatin like 3

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000133115
UniProt:
Q8TAV4
OMIM:
608327
Synonyms:
EPB7.2L, SRO

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.06) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body

References: PMID:41410385, PMID:42010243, PMID:17959775, PMID:21646512, PMID:12122055

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Localizes to Basal Body, mechanosensing channel. BBS4 snd BBS8 knock-out impede its function. (17959775, 21646512). Localised to olfactory cilia of mature olfactory sensory neurons. Involved in olfactory signaling (12122055).