STRADB

STE20 related adaptor beta

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000082146
UniProt:
Q9C0K7
OMIM:
607333
Synonyms:
ALS2CR2, CALS-21, ILPIP, ILPIPA, PAPK

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.98) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=50, lfc=1.04) PMID:30270045

Phenotypes

Mouse phenotype:
decreased mean corpuscular volume

Subcellular localization

cilia, cytosol, nucleus

References: PMID:26585297

Functional category

  • Ciliary assembly/disassembly

Function

The STRADβ-LKB1-MO25 complex appears to localize to the cilium when STRADβ is palmitoylated(26585297).