STYXL1

serine/threonine/tyrosine interacting like 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000127952
OMIM:: 616695
Synonyms:: DUSP24, MK-STYX

Phenotypes

Mouse phenotype:: male infertility

Subcellular localization

cilia, flagella

References: PMID:39743588

Functional category

Small GTPases
Metabolism
Cilia–cytoskeleton/adhesion links

Function

STYXL1 — A motile cilia-associated pseudophosphatase, likely contributing to RS3-associated regulatory mechanisms(39743588). Identified by cryo-EM as a component of radial spoke 3 in sperm flagella and other motile cilia (Leung et al., 2025, Nature, PMID 39743588).

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