SUGT1

SGT1 homolog, MIS12 kinetochore complex assembly cochaperone

Ensembl:
ENSG00000165416
UniProt:
Q9Y2Z0
OMIM:
604098
Synonyms:
SGT1

Cilia effects upon perturbation of SUGT1

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.31) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
embryonic lethality prior to tooth bud stage, preweaning lethality, complete penetrance, embryonic lethality prior to organogenesis, decreased body length

Subcellular localization

basal body, cytosol, flagella, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions
  • Protein processing & maturation
  • Cardiac & muscle development

Function

SUGT1 has localized in basal body,flagella.