SUMO3

small ubiquitin like modifier 3

Ensembl:: ENSG00000184900
UniProt:: P55854
OMIM:: 602231
Synonyms:: SMT3A, SMT3H1

Cilia effects upon perturbation of SUMO3

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.91) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

calyx, connecting piece, flagella, flagellar centriole, nuclear bodies, nucleoplasm

Function

Modification of EVC-EVC2 cytosolic tails with the small ubiquitin-related modifier SUMO3 has a different effect, enhancing complex accumulation at the EvC zone, immediately distal to the ciliary transition zone, possibly via increased binding to the EFCAB7-IQCE complex(PMID: 37576597). SUMO3 has localized in flagella.

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