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synaptotagmin 1

Synonyms:: P65, SVP65, SYT

Subcellular localization

cilia

Function

Three genes-Gfy, Clgn, and Syt1-exhibited transcriptional profiles similar to Rtp1. When coexpressed with an OR, these genes, in combination with Rtp1, promoted cell-surface expression of the tested ORs. Importantly, we demonstrated a physical interaction between Syt1 and an OR (Or1ad1) via co-immunoprecipitation, suggesting a novel role for Syt1 in OR trafficking or stabilization. We also observed localization of Syt1 protein in OSN cilia in both male and female mice. Together, these findings provide new insights into OSN development and the molecular mechanisms underlying OR biogenesis, paving the way for further research into the functional regulation of the olfactory systems. We demonstrated a physical interaction between Syt1 and an OR (Or1ad1) via co-immunoprecipitation, suggesting a novel role for Syt1 in OR trafficking or stabilization. We also observed localization of Syt1 protein in OSN cilia in both male and female mice(41125435).

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