SYTL4

synaptotagmin like 4

Ensembl:: ENSG00000102362
UniProt:: Q96C24
OMIM:: 300723
Synonyms:: SLP4

Cilia effects upon perturbation of SYTL4

Ciliogenesis screen results (5 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.25) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Failler/Valderrama et al. 2021 (siRNA) [siRNA]: Negative Regulator (Ciliogenesis Candidate) PMID:33206585

Phenotypes

Mouse phenotype:: improved glucose tolerance

Subcellular localization

ciliary pocket, vesicles

Functional category

Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

The collection of regulators has diverse distributions throughout the cell with Bfar, Cop1, Cul9, Fancg, Skp1a, Uba3, Ube2l3, and Wwp1 showing weak localization to cilia. In addition, Sytl4 localized to the ciliary pocket at the base of the cilium, and Fbxw11 localized to centriolar satellites . Positive regulator of Hedgehog signaling(PMID: 34161574).

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