TAC1

tachykinin precursor 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000006128
UniProt:
P20366
OMIM:
162320
Synonyms:
NKNA, NPK, TAC2

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body

References: PMID:37296204

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transition zone

Function

SGO-1 likely participates in constraining TAC-1 to the basal body by influencing the function of the transition zone ‘ciliary gate’