TAFAZZIN

tafazzin, phospholipid-lysophospholipid transacylase

Ensembl:: ENSG00000102125
UniProt:: Q16635
OMIM:: 300394
Synonyms:: BTHS, CMD3A, EFE, EFE2, G4.5

Cilia effects upon perturbation of TAFAZZIN

Subcellular localization

basal body

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Metabolism
Cardiac & muscle development
Muscle contraction & physiology

Function

Cytoplasmic retention of YAP/TAZ correlates with active ciliogenesis either in spatially confined cells or in cells treated with an actin filament destabilizer. Moreover, knockdown of YAP/TAZ is sufficient to induce ciliogenesis, whereas YAP/TAZ hyperactivation suppresses serum starvation- mediated ciliogenesis.

Model organism evidence

Mus musculus (1 reference)

Intraflagellar transport (IFT) proteins have been reported to regulate cell growth and differentiation as the essential functional component of primary cilia.

PMIDs: 38287672

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