TAFAZZIN

tafazzin, phospholipid-lysophospholipid transacylase

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000102125
UniProt:: Q16635
OMIM:: 300394
Synonyms:: BTHS, CMD3A, EFE, EFE2, G4.5, TAZ, TAZ1

Subcellular localization

basal body

References: PMID:25849865

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Metabolism
Cardiac & muscle development
Muscle contraction & physiology

Function

Cytoplasmic retention of YAP/TAZ correlates with active ciliogenesis either in spatially confined cells or in cells treated with an actin filament destabilizer. Moreover, knockdown of YAP/TAZ is sufficient to induce ciliogenesis, whereas YAP/TAZ hyperactivation suppresses serum starvation- mediated ciliogenesis.

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