TAGLN2

transgelin 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000158710
UniProt:
P37802
OMIM:
604634
Synonyms:
HA1756, KIAA0120

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.67) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
abnormal skin morphology, increased neutrophil cell number, increased red blood cell distribution width, increased vertical activity, enlarged spleen, increased mean platelet volume, decreased lymphocyte cell number

Subcellular localization

cilia, basal body

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

TAGLN2 has localized in cilia.