TAGLN2

transgelin 2

Ensembl:
ENSG00000158710
UniProt:
P37802
OMIM:
604634
Synonyms:
HA1756, KIAA0120

Cilia effects upon perturbation of TAGLN2

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.67) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
abnormal skin morphology, increased neutrophil cell number, increased red blood cell distribution width, increased vertical activity, enlarged spleen, increased mean platelet volume, decreased lymphocyte cell number
Mouse ciliopathy phenotype:
shortened qrs complex duration, abnormal sternum morphology

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

TAGLN2 has localized in cilia.

Model organism evidence

Mus musculus (1 reference)

IFT20 is a subunit of the intraflagellar transport (IFT) system essential for the formation and function of cilia.

PMIDs: 33748116