TBC1D10A

TBC1 domain family member 10A

Ensembl:
ENSG00000099992
UniProt:
Q9BXI6
OMIM:
610020
Synonyms:
AC004997.C22.2, EPI64, TBC1D10

Cilia effects upon perturbation of TBC1D10A

Cilia number / % ciliated:
Incrased cilia number
Loss-of-function effect:
Longer cilia
Overexpression effect:
Unknown

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=272, lfc=0.83) PMID:30270045

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Protein processing & maturation

Function

Depletion of the GAP TBC1D10A has the opposite effect, resulting in a significant reduction of ARL13B in cilia (PMID: 31432619).

Model organism evidence

Danio rerio (1 reference)

Consistent with these observations, GFP-Rab35 localises to cilia, as do GEF (DENND1B) and GAP (TBC1D10A) Rab35 regulators, which also regulate ciliary length and Rab35 ciliary localisation.

PMIDs: 31432619