TBC1D10A

TBC1 domain family member 10A

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000099992
UniProt:: Q9BXI6
OMIM:: 610020
Synonyms:: AC004997.C22.2, EPI64, TBC1D10

Cilia effects upon perturbation of TBC1D10A

Cilia number / % ciliated:: Incrased cilia number
Loss-of-function effect:: Longer cilia
Overexpression effect:: Unknown

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=272, lfc=0.83) PMID:30270045

Subcellular localization

basal body, cilia

References: PMID:31432619

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Protein processing & maturation

Function

Depletion of the GAP TBC1D10A has the opposite effect, resulting in a significant reduction of ARL13B in cilia (PMID: 31432619).

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