TBC1D10B
TBC1 domain family member 10B
- Ensembl:
- ENSG00000169221
- UniProt:
- Q4KMP7
- OMIM:
- 613620
- Synonyms:
- DKFZP434P1750, EPI64B, FLJ13130, RAB27A-GAPBETA
Cilia effects upon perturbation of TBC1D10B
- Cilia number / % ciliated:
- Unknown
- Loss-of-function effect:
- No effect
- Overexpression effect:
- Unknown
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.52) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Subcellular localization
cilia associated gene
Functional category
- Ciliary assembly/disassembly
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- Ciliary membrane
Function
TBC1D10B is a GTPase-activating protein (GAP) that inactivates Rab GTPases. It is involved in regulating endocytic recycling, a process crucial for maintaining ciliary membrane composition(PMID: 31432619).