TBC1D21

TBC1 domain family member 21

Ensembl:
ENSG00000167139
UniProt:
Q8IYX1
OMIM:
620387
Synonyms:
MGC34741, MGCRABGAP

Cilia effects upon perturbation of TBC1D21

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse ciliopathy phenotype:
male infertility

Subcellular localization

flagella

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion

Function

TBC1D21 has localized in flagella.

Model organism evidence

Mus musculus (4 references)

We previously reported that Tbc1d21-null mice exhibit severe sperm tail defects with a disrupted axoneme, and that TBC1D21 interacts with RAB10.

Male Tbc1d21-/- mice were infertile due to the curved spermatozoa flagella.

PMIDs: 38822685, 35403672, 33536340, 32976492