TBC1D31
TBC1 domain family member 31
- Ensembl:
- ENSG00000156787
- UniProt:
- Q96DN5
- Synonyms:
- GM85, MGC21654, WDR67
Cilia effects upon perturbation of TBC1D31
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- Shorter cilia
Ciliogenesis screen results (2 screens)
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=118, lfc=0.51) PMID:30270045
Phenotypes
- Mouse ciliopathy phenotype:
- increased circulating bilirubin level, increased circulating creatinine level
Subcellular localization
centrosome, cilia
Functional category
- Ciliary assembly/disassembly
Function
TBC1D31 has localized in cilia.