TEK

TEK receptor tyrosine kinase

Ensembl:
ENSG00000120156
UniProt:
Q02763
OMIM:
600221
Synonyms:
CD202B, TIE-2, TIE2, VMCM, VMCM1

Cilia effects upon perturbation of TEK

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased circulating alkaline phosphatase level, abnormal pericardium morphology, embryonic lethality prior to tooth bud stage, preweaning lethality, complete penetrance

Subcellular localization

basal body, lysosomes, ribosome

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development

Function

TEK has localized in basal body.