TEKT1

Cilia effects upon perturbation of TEKT1

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

No effect

Overexpression effect:

Unknown

Ciliogenesis screen results (4 screens)

• Kim2016: No effect
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

abnormal thymus morphology, enlarged thymus, abnormal lymph node morphology, small lymph nodes

Mouse ciliopathy phenotype:

abnormal heart morphology, enlarged heart

Subcellular localization

cilia, flagella, nucleus

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• T cell biology
• Reproduction & sperm
• Cell migration & adhesion
• Transcription regulation

Function

Positive regulator of cilium length. Its expression is controlled by the transcription factor FOXJ1. In zebrafish, it is required for fully efficient motility of cilia in various organs, and for ciliogenesis or mainte nce of motile cilia in the KV. Mutations of which may cause ciliary dyskinesia (29121203).