TEKT2

tektin 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000092850
UniProt:: Q9UIF3
Synonyms:: TEKTB1

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, cilia, flagella, nucleus

References: PMID:42010243, PMID:15340058

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Reproduction & sperm
Cell migration & adhesion

Function

Also known as Tektin-t. Forms filaments in flagellar, ciliary,and axonemal . Required for normal flagellar structure and function. Participates in dynein inner arm assembly or attachment to . Loss of Tektin-t results in impaired motility of cilia and flagella due to deficiency in flagellar construction. Candidate gene for PCD (15340058).

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