TEKT2

tektin 2

Ensembl:
ENSG00000092850
UniProt:
Q9UIF3
Synonyms:
TEKTB1

Cilia effects upon perturbation of TEKT2

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, cilia, flagella, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion

Function

Also known as Tektin-t. Forms filaments in flagellar, ciliary,and axonemal . Required for normal flagellar structure and function. Participates in dynein inner arm assembly or attachment to . Loss of Tektin-t results in impaired motility of cilia and flagella due to deficiency in flagellar construction. Candidate gene for PCD (15340058).

Model organism evidence

Mus musculus (2 references)

Tdrd6 is involved in the formation of the chromatoid body, Tnp2 contributes to the formation of sperm heads, Tekt2 is required for the formation of ciliary and flagellar microtubules, and Klhl10 plays a key role in the elongated sperm differentiation.

TEKT2, which is indispensable for sperm structure, mobility, and fertilization, was present at the periphery of the outer dense fiber (ODF) in the sperm flagella.

PMIDs: 29731491, 24394471