TESK1

testis associated actin remodelling kinase 1

Ensembl:
ENSG00000107140
UniProt:
Q15569
OMIM:
601782

Cilia effects upon perturbation of TESK1

Cilia number / % ciliated:
Incrased cilia number
Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.85) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=4.13, ciliated=69.3%) PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=5.29) PMID:20393562

Phenotypes

Mouse ciliopathy phenotype:
increased circulating alanine transamise level

Subcellular localization

basal body, cilia, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Cell migration & adhesion

Function

Role in the actin dy mics and actin cytoskeleton remodelling, via i ctivation of the actin-severing protein CFL. Supresses ciliogenesis by upregulating the expression of YAP/TAZ target genes, as well as modulating directio l trafficking of ciliary vesicles to the ciliary base. TESK1 overexpression interferes with serum starvation-mediated ciliogenesis (25849865).