TGFB1

transforming growth factor beta 1

Ensembl:
ENSG00000105329
UniProt:
P01137
OMIM:
190180
Synonyms:
CED, DPD1, TGFB, TGFBETA

Cilia effects upon perturbation of TGFB1

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
No effect
Overexpression effect:
Unknown

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia, endosome, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • T cell biology
  • Neurogenesis & migration
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • ECM & connective tissue
  • Transcription regulation

Function

Involved in defective differentiation of ciliated cells (31784664). Regulates the transformation of RPE into fibrous cells (15965172). Increases receptor localisation and activation of SMAD2/3 and ERK1/2 at the ciliary base. TGF-B sig ling is regulated by the primary cilium. Involved in clathrin-dependent endocytosis (CDE) (23746451).