TGFBR1

transforming growth factor beta receptor 1

Ensembl:
ENSG00000106799
UniProt:
P36897
OMIM:
190181
Synonyms:
ACVRLK4, ALK-5, ALK5, ESS1, MSSE

Cilia effects upon perturbation of TGFBR1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • ECM & connective tissue

Function

Phosphorylates and activates downstream effectors MEK1/2-ERK1/2 and receptor SMADs, SMAD2/3 (23746451). Involved in CDE (27364476).