TGIF1

TGFB induced factor homeobox 1

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000177426
UniProt:
Q15583
OMIM:
602630
Synonyms:
HPE4, TGIF

Cilia effects upon perturbation of TGIF1

Cilia number / % ciliated:
Decreased cilia number

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.71) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-2.16) PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=85, lfc=0.73) PMID:30270045

Ciliopathy associations

  • Holoprosencephaly

References: PMID:10835638, PMID:16323008

Subcellular localization

nucleus

References: PMID:27956704

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

Reducing Evi5l expression in MEFs lacking Tgifs resulted in a partial restoration of cilium numbers and in the transcriptional response to activation of the Shh pathway.