TGIF2

TGFB induced factor homeobox 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000118707
UniProt:: Q9GZN2
OMIM:: 607294

Cilia effects upon perturbation of TGIF2

Cilia number / % ciliated:: Decreased cilia number

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.39) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: preweaning lethality, complete penetrance

Subcellular localization

basal body, nucleus

References: PMID:25613900, PMID:27956704

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)
Transcription regulation

Function

Reducing Evi5l expression in MEFs lacking Tgifs resulted in a partial restoration of cilium numbers and in the transcriptional response to activation of the Shh pathway.TGIF2 localized to basal body (25613900)

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.