TIMP3

TIMP metallopeptidase inhibitor 3

Ensembl:
ENSG00000100234
UniProt:
P35625
OMIM:
188826
Synonyms:
SFD

Cilia effects upon perturbation of TIMP3

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.44) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Failler/Valderrama et al. 2021 (siRNA) [siRNA]: Negative Regulator (Ciliogenesis Candidate) PMID:33206585

Phenotypes

Mouse phenotype:
increased mean corpuscular volume
Mouse ciliopathy phenotype:
abnormal reti blood vessel morphology, abnormal reti morphology

Subcellular localization

cilia associated gene, lysosomes, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Ciliary Hedgehog sig ling restricts FAP conversion into adipocytes through TIMP3 and TIMP3 represses injury-induced adipogenesis through inhibition of MMP14 ( 28709001).