TIMP3

TIMP metallopeptidase inhibitor 3

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000100234
UniProt:: P35625
OMIM:: 188826
Synonyms:: SFD

Ciliogenesis screen results (5 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.44) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Failler/Valderrama et al. 2021 (siRNA) [siRNA]: Negative Regulator (Ciliogenesis Candidate) PMID:33206585

Phenotypes

Mouse phenotype:: increased mean corpuscular volume

Subcellular localization

lysosomes, nucleus

References: PMID:28709001

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

Ciliary Hedgehog signaling restricts FAP conversion into adipocytes through TIMP3 and TIMP3 represses injury-induced adipogenesis through inhibition of MMP14 ( 28709001).

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