TJP2

tight junction protein 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000119139
UniProt:
Q9UDY2
OMIM:
607709
Synonyms:
DFNA51, X104, ZO-2, ZO2

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-6.55) PMID:41160700

Phenotypes

Human ciliopathy phenotype:
autosomal dominant nonsyndromic hearing loss

Subcellular localization

basal body, cytosol, flagella, nucleus

References: PMID:40728639

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Reproduction & sperm

Function

ZO-2 colocalizes with CEP164 in the distal appendage of the mother centriole and is also present in the pericentriolar region, mitotic spindle poles, the basal body of primary cilia, and the tail of spermatozoa (PMID: 40728639).