TLR2

toll like receptor 2

Ensembl:
ENSG00000137462
UniProt:
O60603
OMIM:
603028
Synonyms:
CD282, TIL4

Cilia effects upon perturbation of TLR2

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-3.19) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.21) PMID:41160700

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Neurogenesis & migration
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

Toll-like receptor 2 (TLR2), which recognizes BCW, localized at the base of primary cilia in vRGs and the BCW-TLR2 interaction suppressed ciliogenesis leading to derepression of Hedgehog (HH) signaling and expansion of vRGs. TLR6 is an essential partner of TLR2 in this process(PMID: 37052506).

Model organism evidence

Mus musculus (1 reference)

Microbe-associated molecular patterns, including bacterial components, membranes, nucleic acids, and flagella are recognized by TLRs in inflammatory immune responses.

PMIDs: 39336119