TLR4

toll like receptor 4

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000136869
UniProt:
O00206
OMIM:
603030
Synonyms:
ARMD10, CD284, HTOLL, TLR-4

Cilia effects upon perturbation of TLR4

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
enlarged cecum, enlarged uterus, abnormal cecum morphology

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:28927423

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transcription regulation

Function

LPS-induced NF-κB signaling and inflammatory mediator expression are modulated by cilia and that the blockade of primary cilium formation by Kif3a siRNA regulates TLR4-induced NF-κB signaling ( 28927423).