TLR9

toll like receptor 9

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000239732
UniProt:
Q9NR96
OMIM:
605474
Synonyms:
CD289

Cilia effects upon perturbation of TLR9

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Unknown
Overexpression effect:
Unknown

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=3.32) PMID:20393562

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:38538785

Functional category

  • Ciliary assembly/disassembly
  • Metabolism
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

These findings demonstrated that lack of TLR9 disrupts the nuclear and centrosomal DDR machinery so that at the time of CFC, CA1 neurons could not recruit DDR complexes or form cilia and PNNs. (38538785)