TMEM135

transmembrane protein 135

Ensembl:: ENSG00000166575
UniProt:: Q86UB9
OMIM:: 616360
Synonyms:: FLJ22104, PMP52

Cilia effects upon perturbation of TMEM135

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.63) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia associated gene, peroxisome

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

Depletion of peroxisome protein TMEM135 disrupts the intracellular cholesterol distribution. Depletion of TMEM135 blunts Rab8 trafficking and IFT20 trafficking to the centrioles ( 32157776).

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