TMEM232

transmembrane protein 232

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000186952
UniProt:
C9JQI7
OMIM:
620143
Synonyms:
FLJ43080

Cilia effects upon perturbation of TMEM232

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.98) PMID:41160700

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:39516485

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Cell migration & adhesion

Function

TMEM232, as a potential scaffold protein involving in the correct assembly, distribution, and stability maintenance of certain functional complexes by recruiting key intracellular proteins, is essential for the formation of a highly structured flagellum and plays an important role in the autophagic elimination of cytosolic ribosomes to provide energy for sperm motility(PMID: 39516485).