TMEM80

transmembrane protein 80

Ensembl:
ENSG00000177042
UniProt:
Q96HE8
OMIM:
620248
Synonyms:
FLJ38216

Cilia effects upon perturbation of TMEM80

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.66) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

transition zone

Functional category

  • Ciliary assembly/disassembly
  • Transition zone

Function

Repertoire of MKS module-associated proteins—mammalian Tmem80—and suggest an MKS-5 and CEP-290-dependent assembly pathway for building a functional TZ(PMID: 26982032).

Model organism evidence

Mus musculus (1 reference)

TMEM216 promotes primary ciliogenesis and Hedgehog signaling through the SUFU-GLI2/GLI3 axis.

PMIDs: 38261656

Danio rerio (3 references)

TMEM216 promotes primary ciliogenesis and Hedgehog signaling through the SUFU-GLI2/GLI3 axis.

Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants.

PMIDs: 38261656, 36533556, 32687549

C. elegans (1 reference)

Ciliopathies are inherited disorders caused by defects in motile and non-motile (primary) cilia.

PMIDs: 33234550