TNFRSF21

TNF receptor superfamily member 21

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000146072
UniProt:
O75509
OMIM:
605732
Synonyms:
CD358, DR6

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.02) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

References: PMID:40623838

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Tnfrsf21 localized in an atypical ring-shaped pattern at the distal cilium (PMID: 40623838).