TNNT2

troponin T2, cardiac type

Ensembl:: ENSG00000118194
UniProt:: P45379
OMIM:: 191045
Synonyms:: CMD1D, CMH2, CMPD2

Cilia effects upon perturbation of TNNT2

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene, cytosol

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Metabolism
Cardiac & muscle development
Muscle contraction & physiology

Function

There were dysplastic arterial valve leaflets in some cases when Ift88 was deleted in the Tnnt2-Cre lineage suggesting that cilia may be required for the development of the arterial valve leaflets (40498626).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.