TNPO1

transportin 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000083312
UniProt:: Q92973
OMIM:: 602901
Synonyms:: IPO2, KPNB2, MIP, MIP1, TRN

Ciliogenesis screen results (4 screens)

Kim2016: No effect
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-3.04, ciliated=14.4%) PMID:26595381

Subcellular localization

cilia, cytosol, nucleus

References: PMID:21285245, PMID:20526328, PMID:27633000

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

Also known as Importin beta 2. Regulated RP2 trafficking into the ciliary compartment (21285245). Interacts with KIF17, this interaction is required for the ciliary entry of KIF17 (20526328). TNPO1 for a complex with Rab8 and CTSs (ciliary target signals) to mediate selective entry and retention of cargos within cilia (27633000).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.