TOLLIP

toll interacting protein

Ensembl:
ENSG00000078902, ENSG00000291426
UniProt:
Q9H0E2
OMIM:
606277
Synonyms:
IL-1RACPIP

Cilia effects upon perturbation of TOLLIP

Cilia number / % ciliated:
Decreased cilia number

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.61) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, cytosol, endosome, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

TOLLIP accumulates in cilia of ARL6-depleted cells (37019113).