TOM1L2

target of myb1 like 2 membrane trafficking protein

Ensembl:
ENSG00000175662
UniProt:
Q6ZVM7
OMIM:
615519

Cilia effects upon perturbation of TOM1L2

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

The K63-linked ubiquitin chains reader Target of Myb1-like 2 (TOM1L2) directly binds to the BBSome. Targeted disruption of the BBSome-TOM1L2 interaction blocks G protein-coupled receptor exits from cilia(37019113).