TP53

tumor protein p53

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000141510
UniProt:
P04637
OMIM:
191170
Synonyms:
LFS1, P53

Cilia effects upon perturbation of TP53

Cilia number / % ciliated:
Decreased cilia number

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.03) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, incomplete penetrance, decreased circulating creatine kise level, increased startle reflex

Ciliopathy associations

  • Medulloblastoma

References: PMID:26684332, PMID:40562042, PMID:34077761

Subcellular localization

cytosol, microtubules, nucleus, ribosome

References: PMID:26988441

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism
  • Neurogenesis & migration
  • Viral interactions
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transcription regulation

Function

In mice lacking the p53 homolog p73 are recently unified by new analysis showing p73 is required for formation of multiciliated epithelia. p73 directly activates FoxJ1, the central transcriptional driver for multiciliation, and induces a host of genes critical for ciliogenesis ( 26988441).