TP53
tumor protein p53
- Ensembl:
- ENSG00000141510
- UniProt:
- P04637
- OMIM:
- 191170
- Synonyms:
- LFS1, P53
Cilia effects upon perturbation of TP53
- Cilia number / % ciliated:
- Decreased cilia number
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.03) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- preweaning lethality, incomplete penetrance, decreased circulating creatine kise level, increased startle reflex
- Mouse ciliopathy phenotype:
- persistence of hyaloid vascular system, abnormal reti morphology
Ciliopathy associations
- Medulloblastoma
- Mucociliary Clearance Disorder
Subcellular localization
cilia associated gene, cytosol, microtubules, nucleus, ribosome
Functional category
- Ciliary assembly/disassembly
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- Actin & cytoskeleton regulation
- Metabolism
- T cell biology
- Neurogenesis & migration
- Viral interactions
- Protein processing & maturation
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
- Transcription regulation
Function
In mice lacking the p53 homolog p73 are recently unified by new a lysis showing p73 is required for formation of multiciliated epithelia. p73 directly activates FoxJ1, the central transcriptio l driver for multiciliation, and induces a host of genes critical for ciliogenesis ( 26988441).
Model organism evidence
Mus musculus (3 references)
However, they have enlarged apical membranes (called apical endfeet), longer primary cilia, and increased biciliation.
Furthermore, it caused aberrant spermatid flagella assembly alongside defects in sperm head morphology and acrosome structure.