TP63
tumor protein p63
- Ensembl:
- ENSG00000073282
- UniProt:
- Q9H3D4
- OMIM:
- 603273
- Synonyms:
- EEC3, KET, NBP, OFC8, P40
Cilia effects upon perturbation of TP63
- Cilia number / % ciliated:
- Decreased cilia number
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Subcellular localization
cilia, cytosol, nucleus
Functional category
- Ciliary assembly/disassembly
- Signaling (Hedgehog, GPCRs, ion channels)
- Transcription regulation
Function
螖N-Tp63 mediates Wnt/尾-catenin-induced inhibition of differentiation in basal stem cells of mucociliary epithelia, and TP63 is co-localized with acetylated-伪-tubulin in BCs in airway epithelia(31553905).
Model organism evidence
Mus musculus (4 references)
However, they have enlarged apical membranes (called apical endfeet), longer primary cilia, and increased biciliation.
Furthermore, it caused aberrant spermatid flagella assembly alongside defects in sperm head morphology and acrosome structure.