TP63

tumor protein p63

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000073282
UniProt:
Q9H3D4
OMIM:
603273
Synonyms:
EEC3, KET, NBP, OFC8, P40, P51, P53CP, P63, P73H, P73L, SHFM4, TP53CP, TP53L, TP73L

Cilia effects upon perturbation of TP63

Cilia number / % ciliated:
Decreased cilia number

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia, cytosol, nucleus

References: PMID:31553905

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

ΔN-Tp63 mediates Wnt/β-catenin-induced inhibition of differentiation in basal stem cells of mucociliary epithelia, and TP63 is co-localized with acetylated-α-tubulin in BCs in airway epithelia(31553905).