TP73

Cilia effects upon perturbation of TP73

Cilia number / % ciliated:

Decreased cilia number

Loss-of-function effect:

Shorter cilia

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

decreased spleen weight, increased blood urea nitrogen level, thrombocytosis, preweaning lethality, incomplete penetrance

Ciliopathy associations

• Mucociliary Clearance Disorder
• Primary Ciliary Dyskinesia

References: PMID:34077761

Subcellular localization

cytosol, nucleus

References: PMID:42010243, PMID:41410385, PMID:41005307, PMID:25201258, PMID:31028178, PMID:27257214, PMID:26947080

Functional category

• Ciliary assembly/disassembly
• Neurogenesis & migration
• Cell migration & adhesion
• Cardiac & muscle development
• Transcription regulation

Function

Also called P73. Might be critical for the initiation of cilia assembly by indirectly promoting the multiplication of centrosomes (25201258). Transcription factor critical to multiciliogenesis. Required for multiciliated cells differentiation, function and for the direct regulation of transcriptional modulators of multiciliogenesis, including Foxj1, Rfx2 and Rfx3 (31028178, 27257214, 26947080). Required for basal body docking, axonemal extension and motility (27257214).