TPH1

tryptophan hydroxylase 1

Ensembl:
ENSG00000129167
UniProt:
P17752
OMIM:
191060
Synonyms:
TPH, TPRH

Cilia effects upon perturbation of TPH1

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.80) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • T cell biology

Function

DAF-6/intraflagellar transport and the OCR-2/OSM-9 TRPV channel act in concert, regulating two layers of activation of tph-1 in the ADF neurons. The TRPV sig ling turns on tph-1 expression under favorable and aversive conditions, whereas i ctivation of DAF-6 by stress results in further upregulation of tph-1 independently of OCR-2/OSM-9 activity. tph-1 has expression in dendritic cilia of a pair of ADF serotonergic chemosensory neurons(19339602).

Model organism evidence

C. elegans (1 reference)

Mutants of daf-6 or intraflagellar transport constitutively upregulate tph-1 expression.

PMIDs: 19339602