TPH1

tryptophan hydroxylase 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000129167
UniProt:: P17752
OMIM:: 191060
Synonyms:: TPH, TPRH

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.80) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, cytosol

References: PMID:19339602

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

DAF-6/intraflagellar transport and the OCR-2/OSM-9 TRPV channel act in concert, regulating two layers of activation of tph-1 in the ADF neurons. The TRPV signaling turns on tph-1 expression under favorable and aversive conditions, whereas i ctivation of DAF-6 by stress results in further upregulation of tph-1 independently of OCR-2/OSM-9 activity. tph-1 has expression in dendritic cilia of a pair of ADF serotonergic chemosensory neurons(19339602).

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