TPH2

Cilia effects upon perturbation of TPH2

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

no spontaneous movement, abnormal placenta vasculature, increased brain size, enlarged ovary, increased prepulse inhibition, abnormal eye morphology, preweaning lethality, incomplete penetrance, abnormal placenta morphology, decreased locomotor activity, enlarged spleen, abnormal skin morphology, decreased exploration in new environment, increased eosinophil cell number, small liver, abnormal spleen morphology, abnormal ovary morphology

Mouse ciliopathy phenotype:

persistence of hyaloid vascular system, enlarged kidney, abnormal reti vasculature morphology, abnormal brain morphology, abnormal testis morphology, abnormal kidney morphology, enlarged testis, abnormal liver morphology

Subcellular localization

cilia, cytosol

Functional category

• Ciliary assembly/disassembly
• Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

DAF-6/intraflagellar transport and the OCR-2/OSM-9 TRPV channel act in concert, regulating two layers of activation of tph-1 in the ADF neurons. The TRPV sig ling turns on tph-1 expression under favorable and aversive conditions, whereas i ctivation of DAF-6 by stress results in further upregulation of tph-1 independently of OCR-2/OSM-9 activity. tph-1 has expression in dendritic cilia of a pair of ADF serotonergic chemosensory neurons(19339602).

Model organism evidence