TPR

translocated promoter region, nuclear basket protein

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000047410
UniProt:
P12270
OMIM:
189940

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=326, lfc=-3.76) PMID:30270045

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance

Subcellular localization

nucleus

References: PMID:17761526

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

The TPR protein mutant oval/ift88 shows polyglutamylation extending to the tips of cilia ( 17761526).