TPRA1

transmembrane protein adipocyte associated 1

Ensembl:: ENSG00000163870
UniProt:: Q86W33
OMIM:: 608336
Synonyms:: FLJ32197, GPR175, TMEM227, TPRA40

Cilia effects upon perturbation of TPRA1

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, cilia, transition zone

Functional category

Ciliary assembly/disassembly
Transition zone

Function

Also known as GPR175. Positively regulates Hh sig ling via inhibiting PKA activity by lowering cAMP levels. Its ciliary localisation and activity is Hh-dependent (26451044).

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