TRAPPC10

trafficking protein particle complex subunit 10

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000160218
UniProt:
P48553
OMIM:
602103
Synonyms:
EHOC-1, TMEM1, TRS130

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
increased mean platelet volume, increased total body fat amount, increased circulating alkaline phosphatase level, decreased bone mineral content, decreased lean body mass, increased circulating insulin level, decreased mean corpuscular hemoglobin, increased circulating cholesterol level

Subcellular localization

basal body

References: PMID:21273506

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

Component of a mammalian TRAPPII complex. Required for Rabin8 centrosomal targeting prior to ciliogenesis. Knockdown impares cilia formation by inhibiting Rabin8 recruitment to the centrosome (21273506).