TRAPPC12

trafficking protein particle complex subunit 12

Ensembl:
ENSG00000171853, ENSG00000274891
UniProt:
Q8WVT3
OMIM:
614139
Synonyms:
CGI-87, TTC-15, TTC15

Cilia effects upon perturbation of TRAPPC12

Cilia number / % ciliated:
No effect
Loss-of-function effect:
Longer cilia
Overexpression effect:
Unknown

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.73) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, abnormal locomotor behavior

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

TRAPPIII components, TRAPPC8 and TRAPPC12, are in the cilium formation, and TRAPPIII regulates ciliogenesis via its interaction with a ciliopathy protein, OFD1. Depletion causes increased ciliary length because TRAPPC12 is required for the disassembly of primary cilia (32258032).